This book presents research advances in automotive AC systems using an interdisciplinary approach combining both thermal science, and automotive engineering. It covers a variety of topics, such as: control strategies, optimization algorithms, and diagnosis schemes developed for when automotive air condition systems interact with powertrain dynamics. In contrast to the rapid advances in the fields of building HVAC and automotive separately, an interdisciplinary examination of both areas has long been neglected. The content presented in this book not only reveals opportunities when interaction between on-board HVAC and powertrain is considered, but also provides new findings to achieve performance improvement using model-based methodologies.